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Trade namesMany [1]
Pregnancy categoryAU: C US: C (Risk not ruled out)
Routes of administrationOral, rectal, IV, IM, topical
ATC codeD04AA10 ( WHO ) R06AD02 ( WHO )
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Pharmacokinetic data
Bioavailability88% absorbed but after first-pass metabolism reduced to 25% absolute bioavailability [2]
Protein binding93%
MetabolismHepatic glucuronidation and sulfoxidation
Elimination half-life16–19 hours [2] [3]
ExcretionRenal and biliary

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Promethazine blocks the effects of a natural chemical called acetylcholine. It's an offence to drive a car if your ability to drive safely is affected. Promethazine doesn't affect any type of contraception, including the combined pill and emergency contraception. This may be more likely when you first start taking promethazine, but could happen at any time for example, when starting another medicine.

But speak to your doctor before taking any antihistamine if your baby was premature, had a low birth weight, or has health problems. Caffeine has the opposite effect to promethazine on your body and stops it working. Promethazine also blocks the effects of a chemical called dopamine, and this stops you feeling sick. Contact a doctor straight away if:

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It's an offence to drive a car if your ability to drive safely is affected. UK has more information on the law on drugs and driving, related site. Mixing promethazine with herbal remedies and supplements There might be a problem taking some herbal remedies and supplements alongside promethazine, especially ones that cause side effects such as sleepiness, a dry mouth or making it difficult to pee.

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