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| Clinical data | |
|---|---|
| Trade names | Many [1] |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682284 |
| Pregnancy category | AU: C US: C (Risk not ruled out) |
| Routes of administration | Oral, rectal, IV, IM, topical |
| ATC code | D04AA10 ( WHO ) R06AD02 ( WHO ) |
| Legal status | |
| Legal status | AU: S3 (Pharmacist only) CA : OTC UK: P (Pharmacy medicines) (POM when injection), US: ℞-only South Africa: S5 IV S2 Oral |
| Pharmacokinetic data | |
| Bioavailability | 88% absorbed but after first-pass metabolism reduced to 25% absolute bioavailability [2] |
| Protein binding | 93% |
| Metabolism | Hepatic glucuronidation and sulfoxidation |
| Elimination half-life | 16–19 hours [2] [3] |
| Excretion | Renal and biliary |
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Promethazine blocks the effects of a natural chemical called acetylcholine. It's an offence to drive a car if your ability to drive safely is affected. Promethazine doesn't affect any type of contraception, including the combined pill and emergency contraception. This may be more likely when you first start taking promethazine, but could happen at any time for example, when starting another medicine.
But speak to your doctor before taking any antihistamine if your baby was premature, had a low birth weight, or has health problems. Caffeine has the opposite effect to promethazine on your body and stops it working. Promethazine also blocks the effects of a chemical called dopamine, and this stops you feeling sick. Contact a doctor straight away if:
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You can always check with the Pharmacist that you got your prescription filled at they know more about most medications than the doctor. Also whatever the drug was that you got that gave you this problem make sure your regular doctor and Pharmacy have it on record that you have an allergy to it and remember what it is so you can tell any doctor of dentist that you have a drug allergy to it.
Good luck and take it until it is gone.
It's an offence to drive a car if your ability to drive safely is affected. UK has more information on the law on drugs and driving, related site. Mixing promethazine with herbal remedies and supplements There might be a problem taking some herbal remedies and supplements alongside promethazine, especially ones that cause side effects such as sleepiness, a dry mouth or making it difficult to pee.
It's even more dangerous when taken with alcohol or other drugs and has caused people to die.
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Say a noв to alcohol or do not smoke when you are using this medication. Just take one capsule in a span of 24 hours. Overdose may lead to severe health problems.
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Some cough and cold remedies claim to suppress your cough or stop you bringing up phlegm. Pregnancy and breastfeeding Your doctor may want to prescribe promethazine for morning sickness when other treatments haven't worked.
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There isn't enough information available to say whether one antihistamine is better than another for treating allergies. Ask your pharmacist or doctor for advice if you're unsure.
When you come into contact with something you're allergic to, such as pollen or animal hair, your body produces a chemical called histamine. How is it different from other cough and cold remedies? Tips for when you're outside:
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Take the missed dose as soon as you remember.
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