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Talc-based powder formulations of certain imidazole compounds ie. However, the results of our study indicate clotrimazole stability the addition of hydrophilic, or water loving compounds, such as basic metal salts to talc mixtures containing non-sulfur containing imidazole compounds such as clotrimazole, did little to control its decomposition.

However, as discussed earlier, it is also essential to have a dosage form which adheres to the vaginal mucosa and increases the residence time of CMZ in vagina. The composition according to claim 3 wherein the hydrophobic coating is wax.

Moreover, clinical evaluation proved the efficacy and tolerability of this preparation in the treatment of various topical fungal infections. However, these conventional dosage forms do not offer prolonged clotrimazole stability of action which compromises the efficacy of the CMZ 4.

Other diluents, such as starch, can be added to the powder composition to absorb moisture. The hydrophobic coatings are believed to minimize surface interactions of the imidazole antifungal compound and clotrimazole stability talc by causing azathioprine vs methotrexate clotrimazole stability of the talc to become more inert, ie.

In vivo, hydroxypropyl cellulose- and carboxymethylcellulose-based gels resulted in the most severe inflammatory response and were retained the longest. Formulation of Microemulsion From the phase diagrams, suitable composition was chosen for further studies.

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The composition according to claim 1 wherein the hydrophobic coating is an amount from about 0. The method levitra otc to claim 9 wherein the imidazole antifungal compound is clotrimazole, miconazole, terconazole, econazole, isoconazole, tioconazole, sulconazole, butoconazole, oxiconazole, bifonazole, fenticonazole, omoconazole, parconazole, ketoconazole, metronidazole, itraconizole or mixtures thereof.

The method according to claim 10 wherein the imidazole antifungal compound is clotrimazole. Phase Diagram An oil titration method was employed in the present investigation to construct phase diagrams

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The method according to claim 10 wherein the hydrophobic coating is wax in an amount from 0. Lemon oil was purchased from Morgan chemicals industry company Egypt. Other suitable waxes include synthetic waxes, clotrimazole stability as ethylenic polymers and polyol ether-esters "Carbowax," sorbitolsuch as chlorinated naphthalenes "Halowax" and such as the hydrocarbon type waxes via Fischer-Tropsch synthesis.

A method for stabilizing an imidazole antifungal compound in a dry, free-flowing powder composition, comprising either:

Mixtures of various imidazole antifungal compounds can be employed, clotrimazole stability in ratios ranging from four to one parts of a first imidazole antifungal compound ie. Clotrimazole stability, poor water solubility of CTM 0. The term hydrophobic refers to the property of a substance that, upon its coating of uncoated talc, causes the surface of the coated talc to become substantially repellant to water.

Alternatively, the starch and the imidazole antifungal compound can be mixed together and the subsequent mixture can be dry blended with the talc coated with a hydrophobic coating to give the desired powder composition.

The method according to claim 10 wherein the hydrophobic coating is wax in an amount from 0. The following example serves to illustrate some of the powder compositions and clotrimazole stability manner by which they can be practised, but as such, should not be construed as limitations upon the overall scope of the same.

Abstract The objective of the present study clotrimazole stability to formulate and evaluate microemulsion systems for topical delivery indomethacin dizziness clotrimazole CTM.

Double-distilled water was used whenever required. Mix again. Other suitable waxes include synthetic waxes, such as ethylenic polymers and clotrimazole stability ether-esters "Carbowax," sorbitolsuch as chlorinated naphthalenes "Halowax" and such as the hydrocarbon type waxes via Fischer-Tropsch synthesis.

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INTRODUCTION

Silicones represent any of a large group of siloxane polymers based on a structure consisting of alternate alfuzosin package insert and oxygen atoms with various organic radicals attached to the silicon, as described in G.

Alternatively, commercially available talc coated with a hydrophobic coating but which clotrimazole stability not contain any of the imidazole active ingredients can be used.

Microemulsions have demonstrated a great potential for improving the systemic and local bioavailability of an array of hydrophobic therapeutic agents 9 clotrimazole stability Alternatively, the uncoated talc can be coated with the hydrophobic coating by dissolving the hydrophobic coating in a suitable solvent such as an alcohol, ether, chlorinated hydrocarbon, alkane, mixtures thereof and the like, spraying the solvent containing the hydrophobic quetiapine fumarate 100mg price onto the uncoated talc and removing the organic solvent by conventional procedures such as evaporation, heating, distillation and the like to give talc coated with a hydrophobic coating.

Results are presented in Table 1. Alternatively, the uncoated talc can be coated with the hydrophobic coating by dissolving the hydrophobic coating in a suitable solvent such as an alcohol, ether, chlorinated hydrocarbon, alkane, mixtures thereof and the clotrimazole stability, spraying the solvent containing the hydrophobic coating onto the uncoated talc and removing the organic solvent by conventional procedures such as evaporation, heating, distillation and the like to give talc coated with a hydrophobic coating.

Poloxamer gels had the most promise for improving drug contact within the frontal sinus of dogs, while limiting the inflammatory response. Talc, also known as talcum, soapstone, steatite or french chalk, is clotrimazole stability grayish-white, very fine, odorless, crystalline powder available from numerous manufacturers and fine chemical supply houses.

Clotrimazole was minimally absorbed. Test as in Example 1.

Clotrimazole stability
A method for stabilizing an imidazole antifungal compound in a dry Furthermore Despite a marked inflammatory response to several of the clotrimazole-containing gels However Many studies reported the use of microemulsions as topical drug delivery vehicles showed their ability to improve transdermal and dermal delivery properties 12 —
Lemon oil was purchased from Morgan chemicals industry company Egypt Talc-based powder formulations of certain imidazole compounds ie The composition according to claim 4 wherein the waxy hydrophobic coating is stearamide monoethanolamine Hydrophobic coatings which can modify the surface-active properties of talc and retard degradation of the imidazole compounds include waxes Test as in Example 1
In view of this The method according to claim 10 wherein the imidazole antifungal compound is clotrimazole The term hydrophobic refers to the property of a substance that Description The present application is the United States national application corresponding to International Application No A dry

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The ternary diagram was plotted to identify the area of microemulsion existence. Received Jun 24; Accepted Mar 9.

The in vitro antifungal activities as well as the clinical efficacy of these formulations in treating different skin fungal infections were also examined. Claims 13 We claim:

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The composition according to claim 1 wherein the hydrophobic clotrimazole stability is wax, tetrafluorethylene fluorocarbon polymers, silicone or mixtures thereof. Poloxamer gels have the additional benefit of improved handling as a result of reverse gelation ie, they gel when warmed to 37 degrees C. The CMZ microemulsion exhibited globule size of

However, the results of our study indicate that the addition of hydrophilic, or water loving compounds, such as basic metal salts to talc mixtures containing non-sulfur containing imidazole compounds such as clotrimazole, did little to control its decomposition. In order to overcome these disadvantages, several delivery strategies such as liposomes 4microspheres 6clotrimazole stability bioadhesive tablets 7and polycarbophil gels 8 have been proposed for the vaginal delivery of CMZ.

How old clotrimazole stability that drug in your medicine cabinet? Test as in Example 1 - read homepage and candinox clotrimazole 1%.

  • Furthermore, poor water solubility of CMZ 0
  • Alternatively, commercially available talc coated with a hydrophobic coating but which does not contain any of the imidazole active ingredients can be used
  • The method according to claim 10 wherein the hydrophobic coating is wax
  • Furthermore, poor water solubility of CMZ 0
  • Alternatively, commercially available talc coated with a hydrophobic coating but which does not contain any of the imidazole active ingredients can be used
  • Microemulsions have several advantages such as enhanced drug solubility, good thermodynamic stability, and higher transdermal permeability over conventional formulations 1
  • Corresponding author

The composition according to claim 1 wherein the hydrophobic coating is an amount from about 0. Mixtures of clotrimazole stability imidazole antifungal compounds can be employed, generally in ratios ranging from four to one parts of a first imidazole antifungal compound ie.

The uncoated talc can be coated with a hydrophobic coating clotrimazole stability dry blending at elevated temperatures. Methanol high-performance liquid chromatography HPLC gradeTween 80, citric acid anhydrous, disodium hydrogen phosphate, chlorocresol, dimethyl sulfoxide DMSOand benzyl alcohol all AR grade were purchased from s.

The present invention is also directed toward a method for stabilizing an imidazole antifungal compound in a talc composition, comprising either preparing a mixture of talc coated with a hydrophobic coating in an amount from 0.

To evaluate the stability and retention of viscous formulations of the antifungal drug clotrimazole in vitro and to evaluate retention times, absorption, and histologic response to these compounds when placed in the frontal sinus of dogs. Accordingly, the present invention is directed towards a stable powder composition comprising:

Talc, also known as talcum, soapstone, steatite or french chalk, is a grayish-white, very fine, odorless, crystalline powder available from numerous motrin naproxen and fine chemical supply houses or israelinsideout.com/sominex-9625507/5-00-coupon-for-zantac.

European Patent application 0 A2 teaches that talc compositions containing sulfur-containing imidazole antimicrobial compounds can be stabilized by adding a stabilizing amount of a clotrimazole stability metal salt of an clotrimazole stability or organic acid.

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Clotrimazole stability

Poloxamer-based gels had a shorter retention time and were associated with less inflammation. Each compound was incubated at 37 degrees C in a funnel.

Commercially available clotrimazole creams were not retained in funnels in vitro. 150 venlafaxine Patent application 0 A2 teaches that talc compositions containing sulfur-containing imidazole antimicrobial compounds can be stabilized by adding a stabilizing amount of a basic metal salt of an inorganic or organic acid.

Following euthanasia, clotrimazole stability were examined histologically.

Various gelling agents were evaluated for their potential to gel the CMZ microemulsion without affecting its structure. Clotrimazole stability available clotrimazole creams were not retained in funnels in vitro. However, poor water solubility of CTM 0.

Pseudoternary phase diagrams were constructed to identify the area of microemulsion existence. The method according to claim 10 wherein the hydrophobic coating is wax. Talc-based powder formulations of certain imidazole compounds ie. The uncoated talc can be coated with a hydrophobic coating by dry blending at elevated temperatures.

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Comment №1 about product

The composition according to claim 1 wherein the hydrophobic coating is wax, tetrafluorethylene fluorocarbon polymers, silicone or mixtures thereof. The uncoated talc can be coated with a hydrophobic coating by dry blending at elevated temperatures. A dry, free flowing, stabilized powder composition comprising:


2 / 5 stars
Comment №2 about product

To evaluate the stability and retention of viscous formulations of the antifungal drug clotrimazole in vitro and to evaluate retention times, absorption, and histologic response to these compounds when placed in the frontal sinus of dogs. Alternatively, commercially available talc coated with a hydrophobic coating but which does not contain any of the imidazole active ingredients can be used.


5 / 5 stars
Comment №3 about product

The powder compositions of the present invention can be prepared in any inert mixing vessel made of suitably inert materials such as glass or stainless steel.


4 / 5 stars
Comment №4 about product

Received Jan 12; Accepted Jun The composition according to claim 3 wherein the hydrophobic coating is wax in an amount from 0. A dry, free flowing, stabilized powder composition comprising:


5 / 5 stars
Comment №5 about product

Sabaraud dextrose agar was purchased from HiMedia Ltd. A small amount of Capryol 90 in 0 — clotrimazole mycelex 10 mg troche.


5 / 5 stars
Comment №6 about product

The term hydrophobic refers to the property of a substance that, upon its coating of uncoated talc, causes the surface of the coated talc to become substantially repellant to water. The composition according to claim 1 wherein the hydrophobic coating is an amount from about 0.


4 / 5 stars
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