Avoid in recent MI, severe heart failure; if necessary, monitor. Because of the risk to the fetus resulting in premature closure of the ductus arteriosus, diclofenac should be avoided in late pregnancy. Monitor CBCs, blood chemistry, hepatic, and renal function in long-term therapy. Labor and Delivery The effects of diclofenac on labor and delivery in pregnant women are unknown.
Aspirin allergy. These discontinuations were mainly due to skin irritation or related cutaneous adverse reactions. In rats, maternally toxic doses were associated with dystocia, prolonged gestation, reduced fetal weights and growth, and reduced fetal survival.
Because animal reproduction studies are not always predictive of human response, this drug should not be used during pregnancy unless the benefits to the mother justify the potential risk to the fetus, diclofenac potassium dosage for toothache.
These discontinuations were mainly due to skin irritation or related cutaneous adverse reactions. A photococarcinogenicity study with up to 0. No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out.
However, patients with known CV disease or risk factors had a higher absolute incidence of excess serious CV thrombotic events, due to their increased baseline rate. NSAID benzeneacetic acid deriv.
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Physicians and patients should remain alert for the development of such events, throughout the entire treatment course, even in the absence of previous CV symptoms. No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. Adverse Reactions: with .
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Adverse Reactions: The increase in CV thrombotic risk has been observed most consistently at higher doses.
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NSAID benzeneacetic acid deriv. Carcinogenesis, Mutagenesis, Impairment of Fertility There did not appear to be any increase in drug-related neoplasms following daily topical applications of diclofenac sodium gel for 2 years at concentrations up to 0.
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