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3.62 stars from 5, 50 votes 4 reviews
Esomeprazole
Clinical data
Pronunciation/ ˌ ɛ s oʊ ˈ m ɛ p r ə ˌ z oʊ l, - ˈ m iː -, - ˌ z ɒ l / [2]
Trade namesNexium, many others [1]
AHFS/Drugs.comMonograph
MedlinePlusa699054
License dataEU  EMA:  by INN, US   FDA: Esomeprazole
Pregnancy categoryAU: B3 US: C (Risk not ruled out)
Routes of administrationby mouth, IV
Drug classproton pump inhibitor
ATC codeA02BC05 ( WHO )
Legal status
Legal statusAU: S2 (Pharmacy only) UK: General sales list (GSL, OTC) US: ℞-only OTC
Pharmacokinetic data
Bioavailability50 to 90%
MetabolismLiver (CYP2C19, CYP3A4)
Elimination half-life1–1.5 hours
Excretion80% Kidney 20% Faecal

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