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Aldactone (spironolactone, spironolactone) 100 mg, the recommended dose is 50 mg.
Aldactone and you are not experiencing side effects. Try lowering the dose to 25mg.
|Pronunciation||/ ˌ s p aɪ r ə n oʊ ˈ l æ k t oʊ n / SPY -rə-noh- LAK -tohn,  / ˌ s p ɪər -/ SPEER - |
|Trade names||Aldactone, Spiractin, Verospiron, many others; combinations: Aldactazide (+HCTZ), Aldactide (+HFMZ), Aldactazine (+altizide), others|
|Pregnancy category||AU: B3 US: C (Risk not ruled out)|
|Routes of administration||By mouth,  topical |
|Drug class||Antimineralocorticoid; Steroidal antiandrogen|
|ATC code||C03DA01 ( WHO )|
|Legal status||UK: POM (Prescription only) US: ℞-only|
|Bioavailability||60–90%   |
|Protein binding||Spironolactone: 88% (to albumin and AGP)  Canrenone: 99.2% (to albumin) |
|Metabolism||Liver, others: • Deacetylation via CES • S -Oxygenation via FOM • S -Methylation via TMT • Dethioacetylation • Hydroxylation via CYP3A4 • Lactone hydrolysis via PON3)       |
|Metabolites||7α-TS, 7α-TMS, 6β-OH-7α-TMS, canrenone, others    (All three active) |
|Elimination half-life||Spironolactone: 1.4 hours  7α-TMS: 13.8 hours  6β-OH-7α-TMS: 15.0 hrs  Canrenone: 16.5 hours |
|Excretion||Urine, bile |
Non prescription spironolactone
New York: It is available generically and presents an attractive and inexpensive alternative to expensive proprietary medications because of its high efficacy and tolerability for use in select female patients. Paediatric population There is a lack of substantive information from clinical studies on spironolactone in children. See section 4.
Stop using spironolactone and call your doctor at once if you have: If you need surgery, tell the surgeon ahead of time that you are using spironolactone. Too much salt will cause your body to retain water, which may reduce the effectiveness of this medicine.
What should I discuss with my healthcare provider before taking spironolactone? Healthwise, Incorporated, disclaims any warranty or liability for your use of this information.
Tell your aldactone 25 if any of these symptoms are severe or do not go away: Common side effects may include:
Do not use salt substitutes or low-sodium milk products that contain potassium. Any medication that acts on our hormones is called hormonal therapy.
Pfizer, Inc. Quantitative assessment of aldactone 100 sex hormones is unnecessary unless a primary hyperandrogenism is suspected, which includes women who experience severe and sudden onset of acne, hirsutism, and irregular menses Shaw, Archives of Dermatology, 9 Care should be aldactone 100 with severe hepatic and renal impairment which may alter drug metabolism and excretion and coumadin bleeding time.
|Active substance||spironolactone, spironolactone|
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Although hyperkalemia is rare in young healthy women, patients should be counseled to avoid consuming large quantities of high-potassium foods and liquids, such as citrus fruits and melons as well as salt substitutes for seasoning foods. Spironolactone is contraindicated in paediatric patients aldactone 100mg spironolactone moderate to severe renal impairment.
It was first investigated as a aldactone 100mg spironolactone for acne because of its antiandrogen properties in a study published in the British Journal of Dermatology in Goodfellow et al. The dosage recommendations for paediatrics are based upon clinical experience and case studies documented in the scientific literature.
Be sure to mention any of the following: It is not known whether these effects would occur in people using regular doses.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Other drugs may interact with spironolactone, including prescription and over-the-counter aldactone 25, vitaminsand herbal products.
Since ACE inhibitors decrease aldosterone production they should not routinely be used with Aldactone, particularly in patients with marked renal impairment. Your doctor should also know if you have severe heart failure, because hyperkalemia has an increased risk of death in such cases.
Patients who do not tolerate 25 mg once daily may have their dose reduced to 25 mg every other day. Be careful if you drive or do anything that requires you to be alert.
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Aldactone: Uses, Dosage & Side Effects
To make sure spironolactone is safe for you, tell your doctor if you have ever had: The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.
It is not known whether spironolactone will harm an unborn baby and . Complete disclaimer.
You should take this medication only after the appropriate dosages of spironolactone and hydrochlorothiazide are individually established by your doctor. Other uses for this medicine Spironolactone also aldactone 25 used in combination with other medicines to treat precocious puberty a condition causing children to enter puberty too soon, resulting in the development of sexual characteristics in girls usually aldactone 25 than 8 years of age and in boys usually younger than 9 years of age or myasthenia gravis MG, a disease in which the nerves do not function properly and patients may experience weakness; numbness; loss of muscle coordination; and problems with vision, speech, and bladder control.
Can you take tramadol with diclofenac is spironolactone? What other drugs will affect spironolactone?
Maintenance dose should be individually determined. What happens if I overdose? There is limited paediatric data available see sections 5.
The dosage recommendations for paediatrics are based upon clinical experience and case studies documented in the scientific literature. Oral spironolactone use improves acne vulgaris and reduces sebum excretion.
- Hyponatraemia, or hyperkalaemia may be induced, but these effects are unlikely to be associated with acute overdosage
- Do not take extra medicine to make up the missed dose
- Addison's disease an adrenal gland disorder ; high levels of potassium in your blood hyperkalemia ; if you are unable to urinate; or if you are also taking eplerenone
- Spironolactone has been reported to increase serum digoxin concentration and to interfere with certain serum digoxin assays
- Spironolactone shouldn't be used if you have certain kidney problems or conditions associated with hyperkalemia, including the adrenal gland disorder known as Addison's disease
Aldactone 50 mg
Inthe FDA added Stevens-Johnson syndrome and toxic epidermal necrolysis — two life-threatening skin disorders — to spironolactone's list of possible side effects. Patients who do not tolerate 25 mg once daily may have their dose reduced to 25 mg every other day. Take Aldactone exactly as prescribed by your doctor. It is not known whether Aldactone will harm an unborn baby.
Spironolactone helps restore a healthy balance of sodium and potassium in your body. Important Information You should use Aldactone with caution if you have kidney problems, high levels of potassium in your blood, Addison's disease, if you are unable to urinate, or if you are also taking eplerenone.
Copyright Cerner Multum, Inc. Skip the missed dose if it is almost time for your next scheduled dose.
Essential hypertension high blood pressure with an unknown cause Hypokalemia potassium deficiency Edema fluid retention from various conditions, including congestive heart failurekidney disease, and cirrhosis liver scarring Severe heart failure Spironolactone is a potassium-sparing diuretic. If you need surgerytell the surgeon ahead of time that you are using Aldactone.
While using Aldactone, you may need frequent blood tests. Method of administration Administration of Aldactone once daily with a meal is recommended. No specific antidote has been identified. Caution is advised when driving or operating machinery until the response to initial treatment has been determined.
Aldactone drug interactions in more detail Further information Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Aldactone only for the indication prescribed.
Patients who tolerated 25 mg once aldactone 50 mg had their dose increased to 50 mg once daily as clinically indicated. If it proves necessary to adjust the dose of digoxin patients should be carefully monitored for evidence of enhanced or reduced digoxin effect.
Spironolactone is contraindicated for use in paediatric patients with moderate or severe renal impairment; see section 4.
This is a result of several factors: It has a gradual and prolonged action.
Paediatric population Initial daily dosage should provide mg of spironolactone per kilogram body weight given in divided doses. Aldactone also treats fluid retention edema in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome.
For medical advice relating to your personal condition, please consult your doctor. High blood pressure often has no symptoms.
Care should be taken with severe hepatic and renal impairment which may alter drug metabolism and excretion. In rare instances some breast enlargement may persist.
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Electrocardiographic changes are the earliest specific signs of potassium disturbances. Correction of hypokalaemia and hypertension provides presumptive evidence for the diagnosis of primary hyperaldosteronism. Spironolactone has been reported to increase serum aldactone 50 mg concentration and to interfere with certain serum digoxin assays.
Spironolactone or its metabolites may cross the placental barrier. Development appears to be related to both dosage level and duration of therapy and is normally reversible when the drug is discontinued.
While using Aldactone, you may need frequent blood tests. Spironolactone or its metabolites may cross the placental barrier. Patients who tolerate 25 mg once daily may have their dose increased to 50 mg once daily as clinically indicated.
Inthe FDA added Stevens-Johnson syndrome and toxic epidermal necrolysis — two life-threatening skin disorders — to spironolactone's list of possible side effects. Avoid using other potassium-sparing diuretics. The drug may also be used in combination with other medications to treat precocious early puberty and myasthenia gravisa neuromuscular disease. Spironolactone enhances the metabolism of antipyrine.
There is a number of reasons for that. Once you have completed your programme of study to inform you about critical technical service issues relating to a RealNetworks product or service.
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Patients may experience symptoms of volume contraction such as hypotension, orthostasis, and exercise intolerance from the diuresis, all of which may necessitate medication discontinuation. Non-steroidal anti-inflammatory drugs such as aspirin, indomethacin, and mefenamic acid may attenuate the natriuretic efficacy of diuretics due to inhibition of intrarenal synthesis of prostaglandins and have been shown to attenuate the diuretic effect of spironolactone. However, the applicability of animal studies to humans is difficult and is left to individual clinical interpretation.
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Spironolactone has been shown to increase the half-life of digoxin. Spironolactone can also increase the blood levels of lithium, digoxin, and sotalol, increasing the risks for adverse effects and toxicity, as these agents have narrow blood level ranges for therapeutic use.
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A study that used 50 mg spironolactone twice a day on Days 5 through 21 of women's menstrual cycle had a high rate of success with low incidence of side effects Harper, United States, Maintenance dosage should be individually determined and aldactone 25 mg.
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Elderly It is recommended that treatment is started with the lowest dose and titrated upwards as required to achieve maximum benefit. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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Elimination of metabolites occurs primarily in the urine and secondarily through biliary excretion in the faeces. Care should be taken with severe hepatic and renal impairment which may alter drug metabolism and excretion.
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