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Clinical data
Pronunciation/ ˈ aɪ b juː p r oʊ f ɛ n /, / aɪ b juː ˈ p r oʊ f ən /, EYE -bew- PROH -fən
Trade namesAdvil, Motrin, Nurofen, others
License dataEU  EMA:  by INN, US   FDA: Ibuprofen
Pregnancy categoryAU: C US: C (Risk not ruled out) D (US) at ≥30 weeks of gestation, due to the potential for premature closure of the ductus arteriosus
Routes of administrationby mouth, rectal, topical, and intravenous
ATC codeC01EB16 ( WHO ) G02CC01 ( WHO ) M01AE01 ( WHO ) M02AA13 ( WHO ) R02AX02 ( WHO )
Legal status
Legal statusAU: OTC CA : OTC UK: General sales list (GSL, OTC) US: OTC (R x -only at higher doses)
Pharmacokinetic data
Bioavailability80–100% (by mouth), [2] 87% (rectal)
Protein binding98% [1]
MetabolismLiver (CYP2C9) [1]
Onset of action30 min [3]
Elimination half-life2–4 h [4]
ExcretionUrine (95%) [1] [5]

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Ibuprofen Wirkungsdauer wird ibuprofen mindestens 24 Stunden angegeben. Analgesics are prescribed according to a definite time schedule for the long-term treatment of chronic pain.

Die Prostaglandine helfen Immunzellen anzulocken, um den verletzten Bereich zu reparieren. Other interventions, especially if performed by a multiprofessional team with strong expertise in ibuprofen wirkdauer and treating psychosocial and spiritual suffering are a mainstay of pain- therapy of patients with metastatic cancer [ 55 ].

Sustained-release drugs with a duration of action of at least 8 h are used in preference to other preparations.

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